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KMID : 0383820110710060459
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Tuberculosis and Respiratory Diseases
2011 Volume.71 No. 6 p.459 ~ p.463
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A Case of Acute Eosinophilic Pneumonia after Hematopoietic Stem Cell Transplantation
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Park Hwan-Sung
Ok Tae-Jin
Kim You-Jae
Kim Guang-Un
Park So-Eun
An Ji-Hyun
Kim Yun-Ku
Jeong Jae-Ho
Kim Su-Jeong
Lee Yu-Mi
Lee Ho-Su
Kang Bo-Hyoung
Kim Ga-Hee
Kim Dae-Young
Kim Woo-Sung
Kim Dong-Soon
Song Jin-Woo
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Abstract
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Pulmonary complications occur in 40~60% of patients who receive hematopoietic stem cell transplantation (HSCT) and are a source of substantial morbidity and mortality. Acute eosinophilic pneumonia (AEP) is an uncommon, non-infectious pulmonary complication occurring in HSCT recipients. We now report the case of a 52-year-old man with AEP who was treated with allogenic HSCT due to acute myeloid leukemia. He complained of fever, cough and dyspnea 390 days after allogenic HSCT. He also had skin and hepatic graft versus host disease (GVHD). Hypoxemia, diffuse pulmonary infiltrates on a chest x-ray and eosinophilia in bronchoalveolar lavage fluid were also noted in several tests. His symptoms, pulmonary infiltrates, hepatic dysfunction and skin lesions rapidly improved after treatment with corticosteroid therapy. Our case supports the idea that AEP is a late phase non-infectious pulmonary complication and one of the manifestations of chronic GVHD.
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KEYWORD
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Pulmonary Eosinophilia, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease
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